The results were provocative with long-term survival rates higher than anticipated. Phase II pilot studies were conducted that tested the role of surgical resection after induction therapy with either chemotherapy or chemoRT in order to optimize local control after systemic treatment. ( 5- 8) Subsequent phase III trials demonstrated superior survival with concurrent chemoRT compared with sequential administration. ( 1- 4) Addition of chemotherapy to RT (chemoRT) significantly improved survival for this stage subset and is now considered standard care. Historically, patients with stage IIIA non-small-cell lung carcinoma (NSCLC) with clinically-evident, ipsilateral mediastinal nodal metastases (N2) had poor outcomes following single modality treatment with either surgical resection or radiotherapy (RT).
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |